Recent Publications

Adapting and facilitating responses in mouse somatosensory cortex are dynamic and shaped by experience.
Z Dobler*, A Suresh*, T Chari, S Mula, A Tran, DV Buonomano, and C Portera-Cailliau.
Current Biology. 2024. in press doi: 10.1016/j.cub.2024.06.070

The NKCC1 Inhibitor Bumetanide Restores Cortical Feedforward Inhibition and Lessens Sensory Hypersensitivity in Early Postnatal Fragile X Mice.
N Kourdougli, T Nomura, MW Wu, A Heuvelmans, Z Dobler, A Contractor, and C Portera-Cailliau.
Biological Psychiatry. 2024. in press doi: 10.1016/j.biopsych.2024.06.023

Network state transitions during cortical development.
M Wu, N Kourdougli, and C Portera-Cailliau
Nat Rev Neurosci. 2024. in press doi: 10.1038/s41583-024-00824-y

Hypersensitivity to distractors in Fragile X syndrome from loss of modulation of cortical VIP interneurons.
N Rahmatullah, LM Schmitt, L De Stefano, S Post, J Robledo, GR Chaudhari, E Pedapati, CA Erickson, C Portera-Cailliau C, A Goel.
J Neurosci. 2023. in press doi: 10.1523/JNEUROSCI.0571-23.2023

A novel head-fixed assay for social touch in mice uncovers aversive responses in two autism models.
T Chari, A Hernandez, and C Portera-Cailliau.
J Neurosci. 2023. in press doi: 10.1523/JNEUROSCI.0226-23.2023

Improvement of sensory deficits in Fragile X mice by boosting cortical interneuron activity after the critical period.
N Kourdougli, A Suresh, B Liu, P Juarez, A Lin, DT Chung, A Graven Sams, M Gandal, V Martínez-Cerdeño, D Buonomano, B Hall, C Mombereau, and C Portera-Cailliau.
Neuron. 2023. in press doi: 10.1038/s41593-021-00967-6

Two-photon calcium imaging of neuronal activity.
C Grienberger, A Giovannucci, W Zeiger and C Portera-Cailliau.
Nature Reviews Methods Primers. 2022. in press doi: 10.1038/s43586-022-00147-1

aGABRacadabra: A surprising new role for GABAAreceptors in cortical development.
Kourdougli N and C Portera-Cailliau .
Neuron. 2023. in press doi: 10.1016/j.neuron.2022.12.019.

Cortical interneurons in autism.
A Contractor, IM Ethell, and C Portera-Cailliau.
Nature Neuroscience. 2021 November 29. in press doi: 10.1038/s41593-021-00967-6

Barrel cortex plasticity after photothrombotic stroke involves potentiating responses of pre-existing circuits but not functional remapping to new circuits.
WA Zeiger, M Marosi, S Saggi, N Noble, I Samad, and C Portera-Cailliau.
Nature Comm. 2021 June 25. in press doi: 10.1038/s41467-021-24211-8

Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame.
Karpf S, C Riche, D di Carlo, A Goel, WA Zeiger, A Suresh, C Portera-Cailliau and Bahram Jalali.
Nature Comm. 2020 April 28. in press doi: 10.1038/s41467-020-15618-w

EZcalcium: Open Source Toolbox for Analysis of Calcium Imaging Data.
Cantu DA*, B Wang*, MW Gongwer, CX He, A Goel, A Suresh, N Kourdougli, ED Arroyo, W Zeiger, and C Portera-Cailliau.
Frontiers in Neural Circuits. 2020 May 15. doi: 10.3389/fncir.2020.00025

Autism in the Balance: Elevated E-I Ratio as a Homeostatic Stabilization of Synaptic Drive.
A Goel and C Portera-Cailliau.
Neuron. 2019 Feb 20. doi: 10.1016/j.neuron.2019.01.033

Dendritic Spines in Early Postnatal Fragile X Mice Are Insensitive to Novel Sensory Experience.
ED Arroyo, D Fiole, SS Mantri, C Huang, and C Portera-Cailliau.
J Neurosci. 2019 Jan 16. doi: 10.1038/s41380-018-0048-y

Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible.
A Goel, DA Cantu, J Guilfoyle, GR Chaudhari, A Newadkar, B Todisco, D de Alba, LM Schmitt, E Pedapati, CA Erickson, and C Portera-Cailliau.
Nature Neuroscience. 2018 Sep 24. doi: 10.1038/s41593-018-0231-0

A Versatile Method for Viral Transfection of Calcium Indicators in the Neonatal Mouse Brain.
CX He, ED Arroyo, DA Cantu, A Goel, and C Portera-Cailliau.
Front. Neural Circuits. 2018 July 23. doi: 10.3389/fncir.2018.00056

Critical Period Inhibition of NKCC1 Rectifies Synapse Development and Restores Adult Tactile Response Maps in Fragile X Mice.
He Q, ED Arroyo, SN Smukowski, C Piochon, JN Savas, C Portera-Cailliau and A Contractor.
Molec Psychiatry. 2018 Apr 27. doi: 10.1038/s41380-018-0048-y

Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders.
O'Donnell C, Gonçalves JT, Portera-Cailliau C, Sejnowski TJ.
Elife. 2017 Oct11;6. pii: e26724. doi: 10.7554/eLife.26274.

The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning.
Gao J, Marosi M, Choi J, Achiro JM, Kim S, Li S, Otis K, Martin KC, Portera-Cailliau C, Tontonoz P.
Elife. 2017 Sep11;6 pii: e29178. doi: 10.7554/eLife.29178.

Tactile Defensiveness and Impaired Adaptation of Neuronal Activity in the Fmr1 Knock-Out Mouse Model of Autism.
He CX, Cantu DA, Mantri SS, Zeiger WA, Goel A, Portera-Cailliau C.
J Neurosci. 2017 Jul 5;37(27):6475-6487. Epub 2017 Jun 12. doi: 10.1523/JNEUROSCI.0651-17.2017.

The Population Tracking Model: A Simple, Scalable Statistical Model for Neural Population Data.
O'Donnell C, Gonçalves JT, Whiteley N, Portera-Cailliau C, Sejnowski TJ.
Neural Comput. 2017 Jan;29(1):50-93. Epub 2016 Nov 21. doi:10.1162/NECO_a_00910.

Altered Neuronal and Circuit Excitability in Fragile X Syndrome.
Contractor A, Klyachko VA, Portera-Cailliau C.
Neuron. 2015 Aug 19;87(4):699-715. doi: 10.1016/j.neuron.2015.06.017.

Layer 4 pyramidal neurons exhibit robust dendritic spine plasticity in vivo after input deprivation.
Miquelajauregui A, Kribakaran S, Mostany R, Badaloni A, Consalez GG and Portera-Cailliau C.
J Neurosci. 2015. doi: 10.1523/JNEUROSCI.5215-14.2015.

Circuit level defects in the developing neocortex of fragile X mice.
Gonçalves JT, Anstey JE, Golshani P and Portera-Cailliau C.
Nat Neurosci. 2013. Epub 2013 Jun 2. doi: 10.1038/nn.3415.

Altered synaptic dynamics during normal aging.
Mostany R, Anstey JE, Crump, KL,Maco B, Knott, G and Portera-Cailliau C.
J Neurosci. 2013. doi: 10.1523/JNEUROSCI.4825-12.2013.

Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.
Rousso DL, Pearson CA, Gaber ZB, Miquelajauregui A, Li S, Portera-Cailliau C, Morrisey EE and Novitch BG.
Neuron. 2012. doi: 10.1016/j.neuron.2012.02.024.

The trouble with spines in fragile X syndrome: density, maturity and plasticity.
He CX and Portera-Cailliau C.
Neuroscience. 2012. Epub 2012 Apr 20. doi: 10.1016/j.neuroscience.2012.03.049.

Chronic In Vivo Imaging Shows No Evidence of Dendritic Plasticity or Functional Remapping in the Contralesional Cortex after Stroke.
Johnston DG, Denizet M, Mostany R, Portera-Cailliau C.
Cerebral Cortex. 2012. Epub 2012 Apr 11.  doi: 10.1093/cercor/bhs092.

Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice.
Cruz-Martín A, Crespo M, Portera-Cailliau C.
PLoS One. 2012. Epub 2012 Feb 27.  doi: 10.1371/journal.pone.0032446.

Which comes first in fragile X syndrome, dendritic spine dysgenesis or defects in circuit plasticity?
Portera-Cailliau C.
Neuroscientist. 2012. doi: 10.1177/1073858410395322. Epub 2011 May 6.

Absence of large-scale dendritic plasticity of layer 5 pyramidal neurons in peri-infarct cortex.
Mostany R and Portera-Cailliau C.
J Neurosci. 2011. doi: 10.1523/JNEUROSCI.4386-10.2011.

Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing.
Cheng A, Gonçalves JT, Golshani P, Arisaka K and Portera-Cailliau C.
Nature Methods. 2011. Epub 2011 Jan 9.  doi: 10.1038/nmeth.1552.

Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning.
Martin SM, O'Brien GS, Portera-Cailliau C and Sagasti A.
Development. 2010. Epub 2010 Nov 1.  doi: 10.1242/dev.053611.

Local hemodynamics dictate long-term dendritic plasticity in peri-infarct cortex.
Mostany R, Chowdhury TG, Johnston DG, Portonovo SA, Carmichael ST and Portera-Cailliau C.
J Neurosci. 2010. doi: 10.1523/JNEUROSCI.3908-10.2010.

LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells.
Miquelajáuregui A, Varela-Echavarría A, Ceci ML, García-Moreno F, Ricaño I, Hoang K, Frade-Pérez D, Portera-Cailliau C, Tamariz E, De Carlos JA, Westphal H and Zhao Y.
J Neurosci. 2010. doi: 10.1523/JNEUROSCI.5563-09.2010.

Delayed stabilization of dendritic spines in fragile X mice.
Cruz-Martín A, Crespo M and Portera-Cailliau C.
J Neurosci. 2010. doi: 10.1523/JNEUROSCI.0577-10.2010.

Fate of cajal-retzius neurons in the postnatal mouse neocortex.
Chowdhury TG, Jimenez JC, Bomar JM, Cruz-Martin A, Cantle JP, Portera-Cailliau C.
Front Neuroanat. 2010. doi: 10.3389/neuro.05.010.2010.

Developmentally regulated impediments to skin reinnervation by injured peripheral sensory axon terminals.
Brien GS, Martin SM, Söllner C, Wright GJ, Becker CG, Portera-Cailliau C, Sagasti A.
Curr Biol. 2009. Epub 2009 Dec 3. doi: 10.1016/j.cub.2009.10.051.

Internally mediated developmental desynchronization of neocortical network activity.
Golshani P, Gonçalves JT, Khoshkhoo S, Mostany R, Smirnakis S, Portera-Cailliau C.
J Neurosci. 2009. doi: 10.1523/JNEUROSCI.2012-09.2009.

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window.
Holtmaat A, Bonhoeffer T, Chow DK, Chuckowree J, De Paola V, Hofer SB, Hübener M, Keck T, Knott G, Lee WC, Mostany R, Mrsic-Flogel TD, Nedivi E, Portera-Cailliau C, Svoboda K, Trachtenberg JT, Wilbrecht L.
Nature Protocols. 2009. doi: 10.1038/nprot.2009.89

Two-photon axotomy and time-lapse confocal imaging in live zebrafish embryos.
Brien GS, Rieger S, Martin SM, Cavanaugh AM, Portera-Cailliau C, Sagasti A.
J Vis Exp. 2009. Epub 2009 Jul 16. doi: 10.1038/nprot.2009.89.

In vivo 2-photon calcium imaging in layer 2/3 of mice.
Golshani P, Portera-Cailliau C.
J Vis Exp. 2008. doi: 10.3791/681.

A method for 2-photon imaging of blood flow in the neocortex through a cranial window.
Mostany R, Portera-Cailliau C.
J Vis Exp. 2008. doi: 10.3791/678.

A craniotomy surgery procedure for chronic brain imaging.
Mostany R, Portera-Cailliau C.
J Vis Exp. 2008. doi: 10.3791/680.

A familial form of pallidoluysionigral degeneration and amyotrophic lateral sclerosis with divergent clinical presentations.
Portera-Cailliau C, Russ C, Brown RH Jr, Budson AE, Vonsattel JP, Folkerth RD, Corbo JC.
J Neuropathol Exp Neurol. 2007. doi: 10.1097/nen.0b013e318093f40d